(R)-4-bromo-alpha-methylbenzylamine → (R)-1-(2'-methoxy-5'-methyl-biphenyl-4-yl)-ethylamine

Participants

Reaction Steps

Prepared in a similar manner to (R)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid [1-(5′-chloro-2′-ethoxy-biphenyl-4-yl)-ethyl]-amide (Example 1) using 2-methoxy-5-methylphenylboronic acid and (R)-1-(4-bromophenyl)ethylamine to give (R)-1-(2′-methoxy-5′-methyl-biphenyl-4-yl)-ethylamine which was then reacted with 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride. Title compound: 1H NMR (400 MHz, DMSO-d6): δ 8.25 (d, 1H), 7.27 (d, 2H), 7.20 (d, 2H), 7.12 (d, 1H), 7.02 (s, 1H), 6.97 (d, 1H), 4.35 (q, 1H), 3.72 (s, 3H), 3.55 (s, 3H), 2.28 (s, 3H), 2.20 (s, 3H), 1.33 (d, 3H) ppm; MS (ESI) m/z: value [M+H]+.

Provenance & Evidence