1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride → (r)-1,3-Dimethyl-1h-pyrazole-4-sulfonic acid [1-(5'-fluoro-2'-methoxy-biphenyl-4-yl)-ethyl]-amide

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Reaction Steps

Prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) starting with 1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride and 1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 7.41, 7.20 (a/b, 4H), 7.39 (s, 1H), 7.05-6.88 (m, 3H), 4.70 (d, 1H), 4.55 (m, 1H), 3.78 (s, 3H), 3.69 (s, 3H), 2.33 (s, 3H), 1.52 (d, 3H) ppm; MS (ESI) m/z: 404 [M+H]+.

Provenance & Evidence