4-Fluorobenzenesulfonyl chloride → HCID 24769021, compound

HRID 2422858Notes

Reaction equation

HRID 2422858 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][CH3:33])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22](OC(F)(F)F)=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[C:10]([O:30][CH3:31])[CH:9]=2)[CH:7]=1.[F:34]C1C=CC(S(Cl)(=O)=O)=CC=1.FC1C=CC(OC)=C(C2C=CC(CN)=C(OC)C=2)C=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][CH3:33])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH:15][S:16]([C:19]3[CH:20]=[CH:21][C:22]([F:34])=[CH:23][CH:24]=3)(=[O:17])=[O:18])=[C:10]([O:30][CH3:31])[CH:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 24769020HCID 24769020, compoundHCID 67245235HCID 67245235, compound

Product 1

HCID 24769021HCID 24769021, compound

Procedure

Prepared in a similar manner to N-(5′-Fluoro-3,2′-dimethoxy-biphenyl-4ylmethyl)-4-trifluoromethoxy-benzenesulfonamide (Example 16) starting with 4-fluorobenzene sulfonyl chloride and C-(5′-fluoro-3,2′-dimethoxy-biphenyl-4-yl)-methylamine. Title compound: 1H NMR (400 MHz, CDCl3): 7.7-7.8 (m, 2H), 7.0-7.1 (m, 2H), 6.85-7.15 (m, 6H), 5.06-5.15 (m, 1H), 4.21 (d, 2H), 3.76 (s, 3H), 3.77 (s, 3H) ppm; MS (ESI) m/z: 442.0 [M+Na]+.

Sources & evidence

ORD record
ord-a03d468782444dff8c50a027aecdb21e
Source dataset
uspto-grants-2011_06
Patent number
US07960365B2

Reaction notes

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