4-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl Chloride → HCID 87322983, compound

HRID 2422864Notes

Reaction equation

HRID 2422864 reaction equation
[F:1][C:2]([F:33])([F:32])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][C:13]([C@H:16]([NH:18]S(C2C=C(C)OC=2C(F)(F)F)(=O)=O)[CH3:17])=[CH:12][CH:11]=1.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[C:37]([O:45][C:46]([F:49])([F:48])[F:47])[CH:36]=1>>[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([NH:18][C@@H:16]([C:13]2[CH:12]=[CH:11][C:10]([C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[O:3][C:2]([F:1])([F:32])[F:33])=[CH:15][CH:14]=2)[CH3:17])(=[O:43])=[O:42])=[C:37]([O:45][C:46]([F:49])([F:48])[F:47])[CH:36]=1

Participants

3

Reactant 2

HCID 27364214-Bromo-2-(Trifluoromethoxy)Benzene-1-Sulfonyl ChlorideHCID 24768911HCID 24768911, compound

Product 1

HCID 87322983HCID 87322983, compound

Procedure

Prepared in a similar manner to (R)-5-methyl-2-trifluoromethyl-furan-3-sulfonic acid [1-(2′-trifluoromethoxy-biphenyl-4-yl)-ethyl]-amide (Example 3) using 4-bromo-2-trifluoromethoxybenzene sulfonyl chloride instead of 5-methyl-2-trifluoromethyl-4-furan-3-sulfonyl chloride. Title compound: 1H NMR (400 MHz, DMSO-d6): δ 8.65 (d, 1H), 7.7 (d, 1H), 7.6 (d, 1H), 7.55-7.4 (m, 5H), 7.25 (s, 4H), 4.5 (m, 1H), 1.38 (d, 3H) ppm; MS (ESI) m/z: 584.0 [M−H]−.

Sources & evidence

ORD record
ord-6bca6fb9ca924e4187b274ede9b66bd3
Source dataset
uspto-grants-2011_06
Patent number
US07960365B2

Reaction notes

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