4'-Hydroxy-3',5'-dimethylacetophenone → 1-(5'-Fluoro-2'-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethylamine

Participants

Role	Name	HCID	Charge
Reactant	4'-Hydroxy-3',5'-dimethylacetophenone	HCID 36581	—
Reactant	3,5-Dimethylisoxazole-4-sulfonyl chloride	HCID 2736319	—
Reactant	HCID 67244664	HCID 67244664	—
Reactant	N-[1-(2-allyl-5'-fluoro-2'-methoxy-biphenyl-4-yl)-ethyl]-3,4-difluoro-benzenesulfonamide	HCID 67245690	—
Reactant	1-(5'-Fluoro-2'-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethylamine	HCID 67246317	—
Product	1-(5'-Fluoro-2'-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethylamine	HCID 67246317	—
Product	3,5-Dimethyl-isoxazole-4-sulfonic acid [1-(5'-fluoro-2'-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethyl]-amide	HCID 67246880	—

Reaction Steps

1-(5′-Fluoro-2′-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethylamine was prepared in a similar manner to 1-(2-allyl-5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethylamine (Example 34) using 3,5-dimethyl-4-hydroxy acetophenone instead of 3′-allyl-4′-hydroxyacetophenone. The title compound was prepared in a similar manner to N-[1-(2-allyl-5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-3,4-difluoro-benzenesulfonamide (Example 34) using 1-(5′-fluoro-2′-methoxy-2,6-dimethyl-biphenyl-4-yl)-ethylamine and 3,5-dimethyl-isoxazole-4-sulfonyl chloride. MS (ESI) m/z: 433.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960365B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-bfa7e6d5465649dd812605c841f24fbf
Source note	uspto-grants-2011_06