4-Chloro-3-(trifluoromethyl)aniline → N-(Benzimidazol-2-yl)-4-chloro-3-(trifluoromethyl)aniline

HRID 2423029Notes

Reaction equation

HRID 2423029 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][C:13]=1[C:19]([F:22])([F:21])[F:20]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[CH:18][C:12]([Cl:11])=[C:13]([C:19]([F:22])([F:20])[F:21])[CH:14]=1

Participants

3

Reactant 2

HCID 675744-Chloro-3-(trifluoromethyl)anilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 923993N-(Benzimidazol-2-yl)-4-chloro-3-(trifluoromethyl)aniline

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-chloro-3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration and recrystallisation to give the title compound as a hydrochloride salt (white solid, mp 255-260° C.). MS(ES+) m/z 312 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration and recrystallisation

Sources & evidence

ORD record
ord-65ac124bf4434342ab776c060ec5fb14
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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