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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423036Generated: November 2, 2026

2-Chlorobenzimidazole → N-(3,5-Difluorophenyl)-1H-benzimidazol-2-amine

https://huagongshe.com/reaction/2423036

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChlorobenzimidazoleHCID 78572—
Reactant3,5-DifluoroanilineHCID 96595—
ProductN-(3,5-Difluorophenyl)-1H-benzimidazol-2-amineHCID 15604437—

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 3,5-difluoroaniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 292-293° C.). MS(ES+) m/z 246 ([M+1]+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960561B2
Source datasetuspto-grants-2011_06
ORD IDord-8c3d7a1d1083418c8c8fa85231a78f0e
Source noteuspto-grants-2011_06