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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423037Generated: November 3, 2026

3-(Trifluoromethyl)aniline → N-(Benzimidazol-2-yl)-3-(trifluoromethyl)aniline

https://huagongshe.com/reaction/2423037

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)anilineHCID 7375—
Reactant2-ChlorobenzimidazoleHCID 78572—
ProductN-(Benzimidazol-2-yl)-3-(trifluoromethyl)anilineHCID 923987—

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (white solid, mp 160-162° C.). MS(ES+) m/z 278 ([M+1]+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960561B2
Source datasetuspto-grants-2011_06
ORD IDord-5349ac32ae5c490081e1cca39dde2852
Source noteuspto-grants-2011_06