4-Fluoro-3-(trifluoromethyl)aniline → N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423038Notes

Reaction equation

HRID 2423038 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][C:13]=1[C:19]([F:22])([F:21])[F:20]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:16][C:15]1[CH:17]=[CH:18][C:12]([F:11])=[C:13]([C:19]([F:22])([F:20])[F:21])[CH:14]=1

Participants

3

Reactant 2

HCID 753774-Fluoro-3-(trifluoromethyl)anilineHCID 785722-Chlorobenzimidazole

Product 1

HCID 15604438N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 4-fluoro-3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp 255-257° C.). MS(ES+) m/z 296 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration

Sources & evidence

ORD record
ord-7c9f9da12093498880d5c2063d2bf2c9
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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