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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423039Generated: October 30, 2026

4-Fluoro-m-toluidine → N-(4-Fluoro-3-methylphenyl)-1H-benzimidazol-2-amine

https://huagongshe.com/reaction/2423039

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-m-toluidineHCID 67981—
Reactant2-ChlorobenzimidazoleHCID 78572—
ProductN-(4-Fluoro-3-methylphenyl)-1H-benzimidazol-2-amineHCID 15604439—

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 4-fluoro-3-methylaniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (solid, mp 246-248° C.). MS(ES+) m/z 242 ([M+1]+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960561B2
Source datasetuspto-grants-2011_06
ORD IDord-711bb3d0defd4256ad70a69c0670e672
Source noteuspto-grants-2011_06