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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423044Generated: November 1, 2026

2-Chlorobenzimidazole → N-[4-Methyl-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

https://huagongshe.com/reaction/2423044

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChlorobenzimidazoleHCID 78572—
Reactant4-Methyl-3-(trifluoromethyl)anilineHCID 2737715—
ProductN-[4-Methyl-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amineHCID 15602780—

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 4-methyl-3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration to give the title compound as a hydrochloride salt (white solid, mp>265° C.). MS(ES+) m/z 292 ([M+1]+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960561B2
Source datasetuspto-grants-2011_06
ORD IDord-fc4f61c6aa79487e826f466266c8b0e4
Source noteuspto-grants-2011_06