2-Chlorobenzimidazole → N-[2-Fluoro-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

HRID 2423047Notes

Reaction equation

HRID 2423047 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:14][C:13]1[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([F:20])([F:21])[F:22])[C:12]=1[F:11]

Participants

3

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 1455693-Amino-2-fluorobenzotrifluoride

Product 1

HCID 15602783N-[2-Fluoro-3-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 2-fluoro-3-(trifluoromethyl)aniline by Procedure A. The product was isolated by filtration and preparative LCMS to give the title compound as the free base (solid, mp 91-92° C.). MS(ES+) m/z 296 ([M+1]+, 100).

Workup

  1. customThe product was isolated by filtration and preparative LCMS

Sources & evidence

ORD record
ord-29323685505f47178a47b89dde63515d
Source dataset
uspto-grants-2011_06
Patent number
US07960561B2

Reaction notes

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