2-Chlorobenzimidazole → N-[2-Methyl-5-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

Participants

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 3-amino-4-methylbenzotrifluoride by Procedure A. The product was isolated upon basic work-up and purified by preparative LCMS to give the title compound as the free base. 1NMR (DMSO-d6) δ 2.40 (s, 3H), 6.95-7.03 (m, 2H), 7.20-7.25 (m, 1H), 7.31-7.42 (m, 3H), 8.63 (s, 1H), 8.88 (s, 1H), 10.9 (s, 1H). MS(ES+) m/z 292 ([M+1]+, 100).

Provenance & Evidence