2-Aminobiphenyl → N-([1,1'-Biphenyl]-2-yl)-1H-benzimidazol-2-amine

HRID 2423054Notes

Reaction equation

Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 70152-Aminobiphenyl

HCID 785722-Chlorobenzimidazole

Product 1

HCID 15602902N-([1,1'-Biphenyl]-2-yl)-1H-benzimidazol-2-amine

Procedure

The title compound was prepared from 2-chlorobenzimidazole and 2-amino-biphenyl by Procedure A. The crude product was purified by preparative LCMS to give the title compound as the free base (white solid, mp 152-154° C.). MS(ES+) m/z 286 ([M+1]+, 100).

Workup

customThe crude product was purified by preparative LCMS

Sources & evidence

ORD record: ord-4683e5dec9134fb9907f85c61fd4ae60
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960561B2

Reaction notes

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