Hydrochloric Acid → HCID 136085241, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-bromo-5-chloro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole (D23) (0.32 g, 0.74 mmol) in 1,4-dioxane (5 mL)/water (5 mL) was stirred and treated with potassium hydroxide (0.17 g, 3.03 mmol), Pd2 dba3 (0.014 g, 0.015 mmol) and 2-di-tertbutylphosphino-2′,4′,6′-triisopropylbiphenyl (0.019 g, 0.045 mmol) and the mixture was heated to 90° C. under argon. After 3 hrs, the mixture was cooled and water/ethyl acetate were added followed by 2N HCl (1.3 mL) and the product was extracted into ethyl acetate. The combined extracts were washed with brine, dried, concentrated and chromatographed (silica, ethyl acetate/hexane) to give the title compound (D24) (0.195 g)

Provenance & Evidence