HCID 136085238, compound → HCID 135910364, compound

HRID 2423103Notes

Reaction equation

HRID 2423103 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17]CC4C=CC=CC=4)=[C:13]([F:25])[CH:12]=3)[N:6]=[CH:5][C:4]=2[C:3]=1[OH:26]>C(O)C.[Pd]>[F:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([F:25])[CH:12]=3)[N:6]=[CH:5][C:4]=2[C:3]=1[OH:26]

Participants

4

Reactant 1

HCID 136085238HCID 136085238, compound

Product 1

HCID 135910364HCID 135910364, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 5-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol (D17) (610 mg, 1.731 mmol) in ethanol (20 mL) was hydrogenated with 10% palladium on carbon (0.25 g, 2.349 mmol) at room temperature for 2 hrs. The mixture was filtered, concentrated and chromatographed (0-100% EtOAc in hexane) to give the title compound (E10) as an off white solid (290 mg)

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customchromatographed (0-100% EtOAc in hexane)

Sources & evidence

ORD record
ord-4f4b8fdaf8a0413aaf7da186f36943fa
Source dataset
uspto-grants-2011_06
Patent number
US07960563B2

Reaction notes

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