Sodium cyanoborohydride → HCID 25054501, compound

Participants

Reaction Conditions

Reaction Steps

6-Fluoro-1-methyl-8-(phenylsulfonyl)-3,8-dihydro-4H-[1,4]oxazepino[6,7-e]indole (Intermediate 31, 0.010 g, 0.028 mmol) was dissolved in EtOH (2 mL) and NaCNBH3 (3.5 mg, 0.056 mmol) was added. The reaction mixture was heated at 50° C. for 1 hour. The reaction was quenched by addition of water and the solvent was removed under reduced pressure. The crude product was purified by preparative HPLC (XTerra C18, 50 mM NH4HCO3 pH 10-CH3CN) to give the title compound (1.2 mg). MS m/z 361 [M+H]+.

Provenance & Evidence