HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-(1,3-dihydrobenzimidazol-2-ylidene)-1-(3-fluorophenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methylbenzimidazole | HCID 11984 | — |
| Reactant | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(1,3-dihydrobenzimidazol-2-ylidene)-1-(3-fluorophenyl)ethanone | HCID 178520379 | — |
Reaction Steps
3-Fluorobenzoyl chloride was added to a mixture of 2-methylbenzimidazole, triethylamine and dioxane, followed by heating under reflux for 3 hours and cooling to room temperature. Morpholine was added, followed by stirring under heat at 70° C. for 1 hour and work-up to obtain 1-(3-fluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)ethanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960562B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-9932b0cee82643d9b83a981257901cbb |
| Source note | uspto-grants-2011_06 |