Benzyl Bromide → HCID 67244145, compound

Participants

Reaction Steps

At 10° C., cesium carbonate (5.81 g) was added to a DMF (30 mL) solution of 3-fluoro-5-nitrobenzoic acid (2.20 g), followed by stirring for 30 minutes. Then, benzyl bromide (2.07 g) was dropwise added with taking 30 minutes, and then followed by further stirring for 10 minutes. The insoluble matter was separated by filtration, followed by evaporation under reduced pressure. This was subjected to liquid-liquid separation with ether and water added thereto, and the organic layer was dried and then evaporated to obtain benzyl 3-fluoro-5-nitrobenzoate (3.11 g). EI: 275.

Provenance & Evidence