HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423242Generated: November 3, 2026
Thionyl Chloride → 3-(Chlorosulfonyl)-5-fluorobenzoyl chloride
https://huagongshe.com/reaction/2423242
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(chlorosulfonyl)-5-fluorobenzoic acid | HCID 3748704 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 3-(Chlorosulfonyl)-5-fluorobenzoyl chloride | HCID 57780658 | 100.3% |
Reaction Steps
One drop of N,N-dimethylformamide was added to a thionyl chloride (2.03 g) suspension of 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.36 g), followed by stirring at 75° C. for 1 hour. The solvent was evaporated, and this was azeotroped with toluene to obtain 3-(chlorosulfonyl)-5-fluorobenzoyl chloride (1.47 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07960562B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-07191da2f9714a3ca3e72711eca565c4 |
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| Source note | uspto-grants-2011_06 |
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