HCID 178465674, compound → HCID 178465673, compound

Participants

Reaction Steps

10% Pd—C (85 mg) was added to an ethyl acetate (150 mL) suspension of N-({3-[3-(3,5-difluorophenyl)-2-(5-nitro-1,3-dihydro-2H-benzimidazol-2-ylidene)-3-oxopropanoyl]phenyl}sulfonyl)ethanimidamide (845 mg), followed by stirring at room temperature for 22 hours under hydrogen atmosphere (1 atm). The insoluble matter was separated by filtration, washed with ethanol, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform/methanol=30/1), and recrystallized from ethyl acetate/n-hexane to obtain N-({3-[2-(5-amino-1,3-dihydro-2H-benzimidazol-2-ylidene)-3-(3,5-difluorophenyl)-3-oxopropanoyl]phenyl}sulfonyl)ethanimidamide (667 mg).

Provenance & Evidence