Imidazole → HCID 59864892, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-(3-methoxy-4-(4-nitro-2-oxoindolin-5-yloxy)phenyl)acetate (0.177 g, 0.476 mmol) in DCE (10 mL), phosphoryl tribromide (0.273 g, 0.952 mmol) was added dropwise at room temperature. The mixture was heated at 90° C. for 1 h, and then imidazole (0.049 g, 0.714 mmol) was added and heated for another 2 h. The reaction was quenched with ice, adjusted PH to 8 and diluted with ethyl acetate. The organic layer was washed with saturated brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. MS ESI (pos.) m/z: 435.1 (M+H)+

Provenance & Evidence