Lithium hydroxide, monohydrate → HCID 59864909, compound

Participants

Reaction Steps

To a solution of 14.6 (0.020 g, 0.047 mmol) in a mixture of THF/CH3OH/H2O (0.5 mL, ratio=2/2/1), was added LiOH.H2O (0.010 g, 0.220 mmol). The mixture was stirred at room temperature for 1 h. The solution was chromatographed using HPLC to give 14 as a white solid. MS ESI (pos.) m/z: 549.2 (M+H)+. 1H NMR (400 MHz) (CDCl3) δ 8.32 (s, 1H); 7.57 (d, J=7.2 Hz, 1H); 7.20 (s, 1H); 7.11 (d, J=7.2 Hz, 1H); 6.86 (m, 3H); 6.71 (d, J=9.2 Hz, 1H): 6.64 (d, J=8 Hz, 1H); 6.34 (d, J=8 Hz, 1H); 3.80 (s, 3H); 3.62 (s, 2H); 2.53 (s, 3H); 2.33 (s, 3H).

Provenance & Evidence