Trifluoroacetic acid → HCID 178499463, compound

Participants

Reaction Steps

Under an N2 atmosphere, methyl 2-(3-chloro-4-(6-(2,4-dichlorophenylsulfonamido)-2-methyl-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-benzo[d]imidazol-5-yloxy)phenyl)acetate (0.245 g, 0.358 mmol) was dissolved in dichloromethane (4.0 mL). Trifluoroacetic acid (2.5 mL) was added and the reaction was allowed to stir overnight at room temperature. The reaction was diluted with ethyl acetate and saturated NaHCO3 (aq). The layers were separated and the organic layer was dried (Na2SO4), filtered and concentrated in vacuo. Flash column chromatography of the residue, eluting 0% to 7% methanol in dichloromethane, afforded the title compound. LC-MS ESI (pos.) m/z: 555.8 (M+H).

Provenance & Evidence