Hydrochloric Acid → HCID 178432289, compound

Participants

Reaction Steps

Under an N2 atmosphere, methyl 2-(3-chloro-4-(6-(2,4-dichlorophenylsulfonamido)-2-methyl-3H-benzo[d]imidazol-5-yloxy)phenyl)acetate (0.138 g, 0.248 mmol) was dissolved in THF (2.5 mL), and 1N LiOH (2.5 mL) was added. The reaction was allowed to stir at room temperature for 2.5 h. The reaction was brought to pH 5 with 1N HCl and extracted with ethyl acetate. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo. The residue was triturated with an ethyl acetate/hexanes mixture and the product was collected by filtration. LC-MS ESI (pos.) m/z: 541.9 (M+H). 1H NMR (400 MHz) (DMSOd-6) δ 7.76 (d, J=8.5 Hz, 1H); 7.64 (d, J=1.8 Hz, 1H); 7.62 (s, 1H), 7.43-7.40 (m, 2H); 7.10 (d, J=8.2 Hz, 1H); 6.77 (s, 1H); 6.57 (d, J=8.3 Hz, 1H); 3.59 (s, 2H); 2.61 (s, 3H).

Provenance & Evidence