反应详情

N-{4-[3-(4-t-butyl-benzyl)-ureidomethyl]-2-fluoro-6-vinyl-phenyl}methanesulfonamide (15.6 mg, 0.04 mmol) was dissolved in methanol. To the solution was added Pd/C (10 wt. %) and air in the flask was displaced with hydrogen gas. The reaction solution was stirred for 1 hour. After confirming the completion of the reaction with TLC, Pd/C was filtered off through celite. The methanol was removed under reduced pressure and column-chromatographed (n-hexane/ethyl acetate ˜1/1) to yield a white solid (15.8 mg, 100.0%).

1. filtrationwas filtered off through celite
2. customThe methanol was removed under reduced pressure
3. customcolumn-chromatographed (n-hexane/ethyl acetate ˜1/1)