(3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl)methanol → HCID 59709037, compound

Participants

Reaction Steps

To a solution of [3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methanol (2.40 g, 8.39 mmol) in dichloromethane (160 mL) was added pyridinium chlorochromate-silica gel (20.2 wt %, 44.7 g, 41.9 mmol). The mixture was stirred for approximately 1.5 hours and then run through a silica gel pad and concentrated to afford 3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolecarbaldehyde (2.24 g, 7.88 mmol, 94%). 1H-NMR (400 MHz, DMSO-d6) δ 9.89 (s, 1H), 7.64-7.55 (m, 3H), 3.83 (septet, J=7 Hz, 1H), 1.39 (d, J=7 Hz, 6H).

Provenance & Evidence