Ethanol → Ethyl 3-fluoro-4-hydroxybenzoate

HRID 2423560Notes

Reaction equation

HRID 2423560 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([F:1])[CH:3]=1)[CH3:18]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1604563-Fluoro-4-hydroxybenzoic acid

Product 1

HCID 13745619Ethyl 3-fluoro-4-hydroxybenzoate

Procedure

A mixture of 3-fluoro-4-hydroxybenzoic acid (5.0 g), ethanol (100 ml) and concentrated sulfuric acid (1 ml) was refluxed for 1 day. The reaction mixture was poured into ice water, the crystal that was precipitated was filtered, then dried to provide the title compound (24.3 g).

Workup

  1. temperaturewas refluxed for 1 day
  2. customthe crystal that was precipitated
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-d408fa16be874c00a47f35bcbb579eff
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

Loading…