4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

HRID 2423571Notes

Reaction equation

HRID 2423571 reaction equation
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[C:16]([C:18]1[CH:36]=[CH:35][C:21]([O:22][CH2:23][C:24]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:26])[CH3:25])=[C:20]([F:37])[CH:19]=1)#N>>[F:37][C:20]1[CH:19]=[C:18]([CH:16]=[O:4])[CH:36]=[CH:35][C:21]=1[O:22][CH2:23][C:24]([NH:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 86605237Tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate

Product 1

HCID 57934591Tert-butyl[2-(2-fluoro-4-formylphenoxy)-1,1-dimethylethyl]carbamate

Procedure

Synthesized from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 19, tert-butyl [2-(4-cyano-2-fluorophenoxy)-1,1-dimethylethyl]carbamate (1.0 g) was used according to an analogous synthetic method to Preparation Example 20 to provide the title compound (715 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 20

Sources & evidence

ORD record
ord-3b103babcaf24ca4b9ec77079127d85a
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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