HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trichloro-1-(1-methyl-1H-pyrrol-2-yl)-1-ethanone → 1-(4-Bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloro-1-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trichloro-1-(1-methyl-1H-pyrrol-2-yl)-1-ethanone | HCID 2777164 | — |
| Reactant | 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroethanone | HCID 2798140 | — |
| Product | 1-(4-Bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloro-1-ethanone | HCID 11289725 | 81% |
Reaction Steps
Using the same general procedure as used for the synthesis of 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloro-ethanone 7, 5.00 g of 2-trichloroacetyl-1-methylpyrrole afforded 5.46 g (81%) of the title compound 13 as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 7.66 (d, 1H, J=1.2 Hz), 7.42 (d, 1H, J=1.8 Hz), 3.91 (s, 3H); 13C NMR (100 MHz, DMSO-d6) δ 171.48, 134.40, 123.62, 121.19, 95.36, 95.12; HRMS (FAB) calcd for C7H6BrCl3NO (MH+) 303.8698, found 303.8678.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653124B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-32752bd86bc34ef7841359343282d828 |
| Source note | uspto-grants-2014_02 |