HCID 23087242, compound → HCID 66627012, compound

HRID 2423592Notes

Reaction equation

HRID 2423592 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:13][CH:12]=2)=O)=[C:5]([C:26]2[CH2:35][CH2:34][C:33]3[C:28](=[CH:29][C:30]([O:36][CH3:37])=[CH:31][CH:32]=3)[CH:27]=2)[CH:4]=1.COC1C=CC(CC2C=CC(OCCN3CCCCC3)=CC=2)=C(C2CCC3C(=CC(OC)=CC=3)C=2)C=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:13][CH:12]=2)=[C:5]([CH:26]2[CH2:35][CH2:34][C:33]3[C:28](=[CH:29][C:30]([O:36][CH3:37])=[CH:31][CH:32]=3)[CH2:27]2)[CH:4]=1

Participants

3

Reactant 2

HCID 23087242HCID 23087242, compoundHCID 66626928HCID 66626928, compound

Product 1

HCID 66627012HCID 66627012, compound

Procedure

Synthesized from [4-methoxy-2-(7-methoxy-3,4-dihydronaphthalen-2-yl)phenyl][4-(2-piperidin-1-ylethoxy)phenyl]methanone according to an analogous synthetic method to Example 337 described below, the total amount of 1-{2-{4-[4-methoxy-2-(7-methoxy-3,4-dihydronaphthalen-2-yl)benzyl]phenoxy}ethyl}piperidine (274 mg) was used according to an analogous synthetic method to Example 30 described below to provide 1-{2-{4-[4-methoxy-2-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)benzyl]phenoxy}ethyl}piperidine (238 mg). This compound (236 mg) was used according to an analogous synthetic method to Example 111 described below to provide the title compound (75 mg).

Sources & evidence

ORD record
ord-95b99468efbf40fcb4ca0b395f7ea435
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

Loading…