(6-Methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin → [3-Fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-methoxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)phenyl]methanone

Participants

Role	Name	HCID	Charge
Reactant	(6-Methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin	HCID 23087176	—
Reactant	(2-Bromo-4-methoxyphenyl)[3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone	HCID 57934302	—
Product	[3-Fluoro-4-(2-piperidin-1-ylethoxy)phenyl][4-methoxy-2-(6-methoxy-3,4-dihydro-naphthalen-2-yl)phenyl]methanone	HCID 57934461	59.4%

Reaction Steps

Synthesized from (2-bromo-4-methoxyphenyl) [3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]methanone (420 mg) and (6-methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin (352 mg) according to an analogous synthetic method to Example 1, the title compound (295 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960412B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-9251b17cae5f4dd8b839d910a1cb3994
Source note	uspto-grants-2011_06