HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-2-naphthaleneboronic acid → 4-Fluoro-2-(6-methoxynaphthalen-2-yl)phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-2-naphthaleneboronic acid | HCID 4641692 | — |
| Reactant | 5-Fluoro-2-nitrophenyl trifluoromethanesulfonate | HCID 23087161 | — |
| Reactant | 2-(5-Fluoro-2-nitrophenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene | HCID 23087555 | — |
| Product | 4-Fluoro-2-(6-methoxynaphthalen-2-yl)phenylamine | HCID 23087204 | 95.4% |
Reaction Steps
Synthesized from (6-methoxynaphthalen-2-yl)boronic acid and 5-fluoro-2-nitrophenyl trifluoromethanesulfonate according to an analogous synthetic method to Example 24, 2-(5-fluoro-2-nitrophenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene (1.3 g) was used according to an analogous synthetic method to Example 22 to provide the title compound (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960412B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-e996c15683b146bda87cc82419501581 |
| Source note | uspto-grants-2011_06 |