2-Chloro-6-methoxy-3-nitropyridine → 6-Methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)-3-nitropyridine

HRID 2423624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423624
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.COC1N=C([Sn](CCCC)(CCCC)CCCC)C([N+]([O-])=O)=CC=1.FC(F)(F)S(O[C:43]1[CH2:52][CH2:51][C:50]2[C:45](=[CH:46][CH:47]=[C:48]([O:53][CH3:54])[CH:49]=2)[CH:44]=1)(=O)=O>>[CH3:12][O:11][C:4]1[N:3]=[C:2]([C:43]2[CH2:52][CH2:51][C:50]3[C:45](=[CH:46][CH:47]=[C:48]([O:53][CH3:54])[CH:49]=3)[CH:44]=2)[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Komponenten

4

Edukt 3

HCID 27950292-Chloro-6-methoxy-3-nitropyridineHCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087438HCID 23087438, Verbindung

Produkt 1

HCID 230872216-Methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)-3-nitropyridine

Versuchsvorschrift

Synthesized from 2-chloro-6-methoxy-3-nitropyridine according to an analogous synthetic method to Preparation Example 76, 6-methoxy-3-nitro-2-tributylstannylpyridine (5.5 g) and 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (1.5 g) were used according to an analogous synthetic method to Preparation Example 77 to provide 6-methoxy-2-(6-methoxy-3,4-dihydronaphthalen-2-yl)-3-nitropyridine (933 mg). This compound (930 mg) was used according to an analogous synthetic method to Example 30 to provide the title compound (340 mg).

Aufarbeitung

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Quellen und Nachweise

ORD-Eintrag
ord-2a1c46fc50f948ddac33849ef7d1be6b
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

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