4-Bromo-3-nitroanisole → HCID 23087551, compound

HRID 2423671Notes

Reaction equation

HRID 2423671 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[CH:9][S:8][C:7]=2[CH:11]=1.COC1C=CC2C=C(B(O)O)SC=2C=1.Br[C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=1[N+:35]([O-:37])=[O:36]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][C:28]=3[N+:35]([O-:37])=[O:36])[S:8][C:7]=2[CH:11]=1

Participants

4

Reactant 3

HCID 792884-Bromo-3-nitroanisoleHCID 10560276(6-Methoxy-1-benzothiophen-2-yl)boronic acidHCID 136342376-Methoxy-1-benzothiophene

Product 1

HCID 23087551HCID 23087551, compound

Procedure

Synthesized from 6-methoxybenzo[b]thiophene according to an analogous synthetic method to Preparation Example 78, (6-methoxybenzo[b]thiophen-2-yl)boronic acid (3.2 g) and 4-bromo-3-nitroanisole (3.4 g) were used according to an analogous synthetic method to Preparation Example 79 to provide 6-methoxy-2-(4-methoxy-2-nitrophenyl)benzo[b]thiophene (1.7 g). Synthesized from this compound (1.9 g) according to an analogous synthetic method to Example 22, the title compound (1.6 g) was obtained.

Workup

  1. customwere used according to an analogous synthetic method to Preparation Example 79

Sources & evidence

ORD record
ord-e84d9e4a83654c3d80c709f6d7235b0f
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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