3-Bromoanisole → HCID 23087244, compound

HRID 2423676Notes

Reaction equation

HRID 2423676 reaction equation
COC1C=CC(C2CCNC2)=C([N+]([O-])=O)C=1.BrC1C=C(OC)C=CC=1.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH:34]2[CH2:38][CH2:37][N:36]([C:39]3[CH:44]=[CH:43][CH:42]=[C:41]([O:45][CH3:46])[CH:40]=3)[CH2:35]2)=[C:30]([N+:47]([O-])=O)[CH:29]=1>>[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH:34]2[CH2:38][CH2:37][N:36]([C:39]3[CH:44]=[CH:43][CH:42]=[C:41]([O:45][CH3:46])[CH:40]=3)[CH2:35]2)=[C:30]([NH2:47])[CH:29]=1

Participants

4

Reactant 3

HCID 169713-BromoanisoleHCID 23087144HCID 23087144, compoundHCID 23087300HCID 23087300, compound

Product 1

HCID 23087244HCID 23087244, compoundYield 102.3%

Procedure

Synthesized from 3-(4-methoxy-2-nitrophenyl)pyrrolidine and 3-bromoanisole according to an analogous synthetic method to Example 116 described below, 3-(4-methoxy-2-nitrophenyl)-1-(3-methoxyphenyl)pyrrolidine (156 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (145 mg).

Sources & evidence

ORD record
ord-79c025639ddc4cbd882cd1f97627dc37
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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