1-Bromo-2-nitrobenzene → HCID 23087428, compound

HRID 2423677Notes

Reaction equation

HRID 2423677 reaction equation
BrC1C=CC=CC=1[N+]([O-])=O.C([N:18]1[CH2:22][CH2:21][CH:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[N+:29]([O-:31])=[O:30])[CH2:19]1)C1C=CC=CC=1>>[N+:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[CH:20]1[CH2:21][CH2:22][NH:18][CH2:19]1)([O-:31])=[O:30]

Participants

3

Reactant 2

HCID 113411-Bromo-2-nitrobenzeneHCID 23087338HCID 23087338, compound

Product 1

HCID 23087428HCID 23087428, compoundYield 27%

Procedure

Synthesized from 1-bromo-2-nitrobenzene according to an analogous synthetic method to Preparation Example 103, 1-benzyl-3-(2-nitrophenyl)pyrrolidine (1.0 g) was used according to an analogous synthetic method to Preparation Example 104 to provide 3-(2-nitrophenyl)pyrrolidine (184 mg). Synthesized from 3-(2-nitrophenyl)pyrrolidine and 3-bromoanisole according to an analogous synthetic method to Example 116 described below, 1-(3-methoxyphenyl)-3-(2-nitrophenyl)pyrrolidine (141 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (126 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 104

Sources & evidence

ORD record
ord-64af1c195b9d4b4f853f1c89a51118f3
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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