HRID2423730

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：Oc1ccc2c(c1)CCC(c1ccc(O)cc1NCc1ccc(OCCN3CCCCC3)c(F)c1)C2

HCID57934571

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)Oc1ccc2c(c1)CCC(c1ccc(O[Si](C)(C)C(C)(C)C)cc1NCc1ccc(OCCN3CCCCC3)c(F)c1)C2

HCID57934032

未命名化合物

收率 85.3%

PROCEDURE

实验过程

Synthesized from 6-{2-[3-fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol (240 mg) and tert-butyldimethylsilyl chloride (220 mg) according to an analogous synthetic method to Example 201 described below, the title compound (300 mg) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b783703b1f254ee3a1c9432e6535b25a
来源数据集: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07960412B2
来源说明: uspto-grants-2011_06

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[O:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[CH2:5][NH:6][C:7]1[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:8]=1[CH:14]1[CH2:23][CH2:22][C:21]2[CH:20]=[C:19]([OH:24])[CH:18]=[CH:17][C:16]=2[CH2:15]1.[Si:37](Cl)([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38]>>[Si:37]([O:13][C:11]1[CH:10]=[CH:9][C:8]([CH:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][Si:37]([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38])[CH:20]=3)[CH2:15]2)=[C:7]([NH:6][CH2:5][C:4]2[CH:25]=[CH:26][C:27]([O:28][CH2:29][CH2:30][N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)=[C:2]([F:1])[CH:3]=2)[CH:12]=1)([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38]