HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine → 6-{2-{[4-(2-Azepan-1-ylethoxy)benzyl]ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine | HCID 23087318 | — |
| Reactant | 4-(2-Azepan-1-ylethoxy)benzoyl chloride hydrochloride | HCID 86605240 | — |
| Product | 6-{2-{[4-(2-Azepan-1-ylethoxy)benzyl]ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66625745 | 59% |
Reaction Steps
Synthesized from ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (400 mg) and 4-(2-azepan-1-ylethoxy)benzoyl chloride hydrochloride (530 mg) according to an analogous synthetic method to Example 187, the title compound (390 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960412B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-9c4392fe89d141a9b75eed49fb029e9e |
| Source note | uspto-grants-2011_06 |