Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine → HCID 57934114, compound

HRID 2423740Notes

Reaction equation

HRID 2423740 reaction equation
C(NC1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)C.Cl.FC1C=C(C=CC=1CCCN1CCCCC1)C(O)=O.[CH2:44]([N:46]([CH2:67][C:68]1[CH:73]=[CH:72][C:71]([CH2:74][CH2:75][CH2:76][N:77]2[CH2:82][CH2:81][CH2:80][CH2:79][CH2:78]2)=[C:70]([F:83])[CH:69]=1)[C:47]1[CH:52]=[C:51]([O:53]C)[CH:50]=[CH:49][C:48]=1[CH:55]1[CH2:64][CH2:63][C:62]2[C:57](=[CH:58][CH:59]=[C:60]([O:65]C)[CH:61]=2)[CH2:56]1)[CH3:45]>>[CH2:44]([N:46]([CH2:67][C:68]1[CH:73]=[CH:72][C:71]([CH2:74][CH2:75][CH2:76][N:77]2[CH2:82][CH2:81][CH2:80][CH2:79][CH2:78]2)=[C:70]([F:83])[CH:69]=1)[C:47]1[CH:52]=[C:51]([OH:53])[CH:50]=[CH:49][C:48]=1[CH:55]1[CH2:64][CH2:63][C:62]2[CH:61]=[C:60]([OH:65])[CH:59]=[CH:58][C:57]=2[CH2:56]1)[CH3:45]

Participants

4

Reactant 3

HCID 23087318Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amineHCID 66625597HCID 66625597, compoundHCID 66627305HCID 66627305, compound

Product 1

HCID 57934114HCID 57934114, compoundYield 89.5%

Procedure

Synthesized from ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine and 3-fluoro-4-(3-piperidin-1-ylpropyl)benzoic acid hydrochloride according to an analogous synthetic method to Example 152, ethyl[3-fluoro-4-(3-piperidin-1-ylpropyl)benzyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (377 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (320 mg).

Sources & evidence

ORD record
ord-e75ceb51b675460e91c4c9e60e9ea02b
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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