3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid → 6-{2-{Ethyl[3-(1-methylpiperidin-4-yl)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Participants

Role	Name	HCID	Charge
Reactant	3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid	HCID 45073791	—
Reactant	6-(2-(Ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl pivalate	HCID 57934095	—
Product	6-{2-{Ethyl[3-(1-methylpiperidin-4-yl)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol	HCID 57933801	38.4%

Reaction Steps

Synthesized from pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (80 mg) and 4-(3-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (100 mg) according to an analogous synthetic method to Example 337 described below, the title compound (39 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960412B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-fea5720e668e4210b2bc5a519371d43a
Source note	uspto-grants-2011_06