Tetrabutylammonium Fluoride → HCID 71087311, compound

Participants

Reaction Steps

The compound (0.910 g) obtained in (2) was dissolved in THF (10 mL), followed by addition of TBAF (1.0 M THF solution, 4.08 mL) under stirring, and the stirring was continued for 21 hours. The reaction solution was diluted with ethyl acetate, washed with saturated brine, and subsequently dried over anhydrous magnesium sulfate to distill off the solvent under reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/hexane=20%→100%) using amino column (product name: Hi-Flash Column 2 L, manufactured by Yamazen Corporation) to afford the title compound (0.170 g).

Provenance & Evidence