Ammonia → pivalic acid (R)-6-{2-{ethyl[4-(piperidin-4-yloxy)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

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Reaction Steps

Synthesized from (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 4-(4-formylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (72 mg) according to an analogous synthetic method to Example 212, to a solution of the resulting (R)-4-{4-{{{2-[6-(2,2-dimethylpropionyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}ethylamino}methyl}phenoxy}piperidine-1-carboxylic acid tert-butyl ester crude product in dichloromethane (0.5 ml) was added trifluoroacetic acid (0.5 ml), the solution was let to stand for 30 minutes at room temperature, then neutralized with ammonia solution, extracted with chloroform, then concentrated under a nitrogen stream to give pivalic acid (R)-6-{2-{ethyl[4-(piperidin-4-yloxy)benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester. Synthesized from the total amount of the resulting crude product according to an analogous synthetic method to Example 213 and purified by LC-MS, the title compound (5.0 mg) was obtained.

Provenance & Evidence