HCID 57934423, compound → HCID 66627789, compound

HRID 2423802Notes

Reaction equation

HRID 2423802 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[C@@H:14]1[CH2:23][CH2:22][C:21]2[CH:20]=[C:19]([O:24]C(=O)C(C)(C)C)[CH:18]=[CH:17][C:16]=2[CH2:15]1)[CH3:2].[CH:31]([C:33]1[CH:53]=[CH:52][C:36]([O:37][CH2:38][C:39]2([NH:44]C(=O)OC(C)(C)C)[CH2:43][CH2:42][CH2:41][CH2:40]2)=[CH:35][CH:34]=1)=O>>[NH2:44][C:39]1([CH2:38][O:37][C:36]2[CH:52]=[CH:53][C:33]([CH2:31][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=3[C@@H:14]3[CH2:23][CH2:22][C:21]4[CH:20]=[C:19]([OH:24])[CH:18]=[CH:17][C:16]=4[CH2:15]3)=[CH:34][CH:35]=2)[CH2:43][CH2:42][CH2:41][CH2:40]1

Participants

3

Reactant 2

HCID 57934423HCID 57934423, compoundHCID 57934541pivalic acid (R)-6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66627789HCID 66627789, compoundYield 93.1%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl [1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (24 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-7a5d8e13e84b4532b9176efa0746a67c
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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