HCID 23087231, compound → HCID 66625602, compound

HRID 2423835Notes

Reaction equation

HRID 2423835 reaction equation
COC1C=CC(C2C(C)(C)C3C(CC=2)=CC(OC)=CC=3)=C(N)C=1.Cl.[F:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][C:34]=1[O:35][CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1)[C:29](O)=O.FC1C=[C:47](C=CC=1OCCN1CCCCC1)[CH2:48][NH:49][C:50]1[CH:55]=[C:54]([O:56][CH3:57])[CH:53]=[CH:52][C:51]=1[C:58]1[C:59]([CH3:71])([CH3:70])[C:60]2[C:65]([CH2:66][CH:67]=1)=[CH:64][C:63]([O:68][CH3:69])=[CH:62][CH:61]=2>>[CH2:48]([N:49]([CH2:29][C:28]1[CH:32]=[CH:33][C:34]([O:35][CH2:36][CH2:37][N:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)=[C:26]([F:25])[CH:27]=1)[C:50]1[CH:55]=[C:54]([O:56][CH3:57])[CH:53]=[CH:52][C:51]=1[C:58]1[C:59]([CH3:70])([CH3:71])[C:60]2[C:65]([CH2:66][CH:67]=1)=[CH:64][C:63]([O:68][CH3:69])=[CH:62][CH:61]=2)[CH3:47]

Participants

4

Reactant 3

HCID 23087231HCID 23087231, compoundHCID 666268273-Fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochlorideHCID 66627351HCID 66627351, compound

Product 1

HCID 66625602HCID 66625602, compound

Procedure

Synthesized from 5-methoxy-2-(6-methoxy-1,1-dimethyl-1,4-dihydronaphthalen-2-yl)phenylamine and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride according to an analogous synthetic method to Example 114, [3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(6-methoxy-1,1-dimethyl-1,4-dihydronaphthalen-2-yl)phenyl]amine (316 mg) was used according to an analogous synthetic method to Example 36 to provide ethyl [3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(6-methoxy-1,1-dimethyl-1,4-dihydronaphthalen-2-yl)phenyl]amine (82 mg). The total amount of this compound was used according to an analogous synthetic method to Example 111 to provide the title compound (62 mg).

Sources & evidence

ORD record
ord-db0e81fce6de430eaffcafef6338d2aa
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

Loading…