1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine → HCID 57933878, compound

HRID 2423847Notes

Reaction equation

HRID 2423847 reaction equation
COC1C=CC(C2SC3C=CC(OC)=CC=3C=2)=C(N)C=1.BrC1C=CC(OCCN2CCCCC2)=C(F)C=1.[F:38][C:39]1[CH:40]=[C:41]([NH:54][C:55]2[CH:60]=[C:59]([O:61]C)[CH:58]=[CH:57][C:56]=2[C:63]2[S:67][C:66]3[CH:68]=[CH:69][C:70]([O:72]C)=[CH:71][C:65]=3[CH:64]=2)[CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1>>[F:38][C:39]1[CH:40]=[C:41]([NH:54][C:55]2[CH:60]=[C:59]([OH:61])[CH:58]=[CH:57][C:56]=2[C:63]2[S:67][C:66]3[CH:68]=[CH:69][C:70]([OH:72])=[CH:71][C:65]=3[CH:64]=2)[CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1

Participants

4

Reactant 3

HCID 230870721-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidineHCID 23087315HCID 23087315, compoundHCID 23087346HCID 23087346, compound

Product 1

HCID 57933878HCID 57933878, compoundYield 76.2%

Procedure

Synthesized from 5-methoxy-2-(5-methoxybenzo[b]thiophen-2-yl)phenylamine and 1-[2-(4-bromo-2-fluorophenoxy)ethyl]piperidine according to an analogous synthetic method to Example 116, [3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl][5-methoxy-2-(5-methoxybenzo[b]thiophen-2-yl)phenyl]amine (300 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (216 mg).

Sources & evidence

ORD record
ord-fa1aaf4a461049e593e5df37ccf961df
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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