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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2423866Generated: October 30, 2026

4-Hydroxyphthalic acid → 5-Hydroxy-2-{5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl} isoindole-1,3-dione

https://huagongshe.com/reaction/2423866

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Hydroxyphthalic acidHCID 11881—
Reactant5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamineHCID 11219085—
Product5-Hydroxy-2-{5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl} isoindole-1,3-dioneHCID 23087065110.6%

Reaction Steps

Synthesized from 5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamine (1.5 g) and 4-hydroxyphthalic acid (1.6 g) according to an analogous synthetic method to Preparation Example 112, the title compound (2.6 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960412B2
Source datasetuspto-grants-2011_06
ORD IDord-268b57d8ad304f53b6fc489248defb46
Source noteuspto-grants-2011_06