HCID 66627207, compound → HCID 66627208, compound

HRID 2423896Notes

Reaction equation

HRID 2423896 reaction equation
[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13](=O)[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)[CH3:2].[CH2:42](N(C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)CC1C=CC(OCCN2CCNCC2)=CC=1)C>>[CH2:1]([N:3]([C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[CH:30]1[CH2:39][CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[C:35]([O:40][CH3:41])[CH:36]=2)[CH2:31]1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][N:17]([CH3:42])[CH2:18][CH2:19]2)=[CH:7][CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66627207HCID 66627207, compoundHCID 66627277HCID 66627277, compound

Product 1

HCID 66627208HCID 66627208, compound

Procedure

Synthesized from N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-4-(2-oxo-2-piperazin-1-ylethoxy)benzamide according to an analogous synthetic method to Example 337, ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl][4-(2-piperazin-1-ylethoxy)benzyl]amine (650 mg) was used according to an analogous synthetic method to Preparation Example 18 to provide ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl}amine (490 mg). The total amount of this compound was used according to an analogous synthetic method to Example 111 to provide the title compound (70 mg).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 18

Sources & evidence

ORD record
ord-4d232619bdf0499c922c368ef114e654
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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