[2-(4-Benzyloxyphenyl)ethyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine → 4-{2-{[5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]methylamino}ethyl}phenol

HRID 2423903Notes

Reaction equation

HRID 2423903 reaction equation
C(OC1C=CC(CCNC2C=C(OC)C=CC=2C2CCC3C(=CC=C(OC)C=3)C2)=CC=1)C1C=CC=CC=1.C([O:45][C:46]1[CH:51]=[CH:50][C:49]([CH2:52][CH2:53][NH:54][CH2:55][C:56]2[CH:61]=[C:60]([O:62][CH3:63])[CH:59]=[CH:58][C:57]=2[CH:64]2[CH2:73][CH2:72][C:71]3[C:66](=[CH:67][CH:68]=[C:69]([O:74][CH3:75])[CH:70]=3)[CH2:65]2)=[CH:48][CH:47]=1)C1C=CC=CC=1>>[CH3:63][O:62][C:60]1[CH:59]=[CH:58][C:57]([CH:64]2[CH2:73][CH2:72][C:71]3[C:66](=[CH:67][CH:68]=[C:69]([O:74][CH3:75])[CH:70]=3)[CH2:65]2)=[C:56]([CH2:55][NH:54][CH2:53][CH2:52][C:49]2[CH:50]=[CH:51][C:46]([OH:45])=[CH:47][CH:48]=2)[CH:61]=1

Participants

3

Reactant 2

HCID 23087307[2-(4-Benzyloxyphenyl)ethyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amineHCID 86605255[2-(4-Benzyloxyphenyl)ethyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]methylamine

Product 1

HCID 666275064-{2-{[5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]methylamino}ethyl}phenolYield 106%

Procedure

Synthesized from [2-(4-benzyloxyphenyl)ethyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine according to an analogous synthetic method to Preparation Example 18, [2-(4-benzyloxyphenyl)ethyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]methylamine (367 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (320 mg).

Sources & evidence

ORD record
ord-d007c0c6499a4f48a025fac404c314bb
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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