Piperidine, 1-(2-chloroethyl)-, hydrochloride → Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{2-[4-(2-piperidin-1-ylethoxy)phenyl]ethyl}amine

Participants

Role	Name	HCID	Charge
Reactant	Piperidine, 1-(2-chloroethyl)-, hydrochloride	HCID 74826	—
Reactant	4-{2-{Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amino}ethyl}phenol	HCID 23087110	—
Product	Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{2-[4-(2-piperidin-1-ylethoxy)phenyl]ethyl}amine	HCID 57934307	95.8%

Reaction Steps

Synthesized from 4-{2-{ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amino}ethyl}phenol (302 mg) and 1-(2-chloroethyl)piperidine hydrochloride (168 mg) according to an analogous synthetic method to Preparation Example 40, the title compound (364 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960412B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-c807ea73d3bd43b2a8c6a50a913a8bbb
Source note	uspto-grants-2011_06